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2007 Annual Report

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Argonne National

Argonne National Laboratory Argonne, IL University of Illinois Champaign-Urbana, IL University of Chicago Chicago, IL Northern Illinois University DeKalb, IL Evanston Northwestern Healthcare Evanston, IL Northwestern University Evanston, IL Immtech Pharmaceuticals Vernon Hills, IL University of Wisconsin - Madison Madison, WI University of Cincinnati Cincinnati, OH Ohio State University College of Medicine & Public Health Columbus, OH Fred Hutchinson Cancer Research Center Seattle, WA University of Washington Seattle, WA University of Utah Salt Lake City, UT Nevada Cancer Institute Las Vegas, NV University of California San Fransisco & Los Angeles, CA Orphagen Pharmaceuticals San Diego, CA TGEN Phoenix, AZ University of New Mexico Albuquerque, NM University of Toronto Toronto, Ontario, Canada VisualSonics, Inc. Toronto, Ontario, Canada Washington University St. Louis, MO University of Nebraska Omaha, NE Mary Crowley Cancer Center Dallas, TX University of Texas Southwestern Medical Center Dallas, TX University of Texas Medical Branch at Galveston Galveston, TX Baylor Breast Center Houston, TX Baylor College of Medicine Houston, TX M.D. Anderson Cancer Center Houston, TX The Methodist Hospital Houston, TX University of Alabama - Birmingham Birmingham, AL McGill Cancer Center Montreal, Quebec, Canada University of Montreal Montreal, Quebec, Canada Beth Israel Deaconess Medical Center Boston, MA Harvard University Boston, MA Massachusetts Institute of Technology Cambridge, MA Novartis Institutes for Biomedical Research Cambridge, MA Waters Corporation Milford, MA Rosewell Park Cancer Institute Buffalo, NY Albert Einstein Medical School Bronx, NY New York University New York, NY Schering-Plough Research Institute Kenilworth, NJ New Jersey Medical School Newark, NJ Muhlenberg College Allentown, PA Lankenau Research Institute Philadelphia, PA Assoc. of American Cancer Institutes Pittsburgh, PA University of Pittsburgh Pittsburgh, PA Johns Hopkins University Baltimore, MD National Institutes of Health Bethesda, MD -Nat’l Cancer Institute - Genetics Branch -Nat’l Institute of Neurological Disorders and Stroke -Nat’l Institute of Dental and Craniofacial Research -Nat’l Institute of Neurological Disorders and Stroke Assoc. of Independent Research Institutes Westminster, MD Duke University Durham, NC East Tennessee State University Johnson City, TN Vanderbilt University Nashville, TN Federal University of Rio de Janeiro Rio de Janeiro, Brazil St. James’s Hospital Dublin, Ireland University of Birmingham Birmingham, United Kingdom Medical Research Council Center Cambridge England University of Cambridge Cambridge, England University of Gothenburg Gothenburg, Sweden Faculté de Médecine Paris-Sud Paris, France Norwegian University of Science and Technology Trondheim, Norway Karolinska Hospital Stockholm, Sweden University Hospital Lund, Sweden Dusseldorf University Dusseldorf, Germany Technische Universität Munich, Germany Aristotle University of Thessaloniki Thessaloniki, Greece Leiden University Medical University Leiden, The Netherlands University of Helsinki Helsinki, Finland Tel Aviv University Tel Aviv, Israel Van Andel Research Institute

Nanjing Medical University Antibody Technology Development Program Nanjing, China University of Malaya Kuala Lumpur, Malaysia Yansei University Seoul, South Korea Tianjin Cancer Institute & Hospital Tianjin, China Guangzhou University Guangdong Province, China Sun Yat-sen University Guangzhou, China Singapore General Hospital Singapore National Cancer Centre Translational Research Program Singapore National University of Singapore Singapore New in 2007 National Cancer Centre Translational Research Program VAI Distinguished Scientific Investigator Bin Teh, M.D., Ph.D., directs the Translational Research Program, a collaboration with the National Cancer Center, Singapore (NCCS), that focuses on the biology behind varying drug responses in Asian versus non-Asian cancer patients. The program provides a larger patient base for rare cancers – 55 percent of all cancer cases in Singapore are captured by the NCCS network. New in 2007 Compassionate Care Protocol Craig Webb, Ph.D., director of VAI’s Program of Translational Medicine, spearheads the Compassionate Care Protocol, a study by VAI and several clinical partners that aims to provide personalized medicine to advanced-stage cancer patients. Using a database developed by Webb’s lab, detailed molecular and genetic data from patients’ tumors helps determine which unique combination of drugs will have the greatest impact on treatment. The study continues in 2008 with the hope of including up to 200 local cancer patients. Iwate Medical University Morioka, Japan Kitasato University School of Medicine Kanagawa, Japan University of Tokushima Tokushima, Japan University of Queensland Brisbane, Australia Griffith University Nathan, Queensland, Australia University of Sydney Sydney, Australia Collaborations One of Van Andel Institute’s founding principles is to collaborate with local, national, and international scientists and organizations. Collaborations quicken the pace of progress, opening up new avenues of research and generating new ideas. Many of our research collaborations from 2007 are represented on the map to the left; you can see that Van Andel Institute is not only connected to our local community, but to a world of partners. Collaborations Close to Home Ann Arbor, MI > Department of Veterans Affairs Healthcare System > Lansing Reveal Technologies > Pfizer (also St. Louis, MO and Groton, CT locations) > University of Michigan Detroit, MI > Barbara Ann Karmanos Institute > Henry Ford Hospital > Wayne State University Grand Rapids, MI > Academic Surgical Associates > Advanced Radiology Services > Cancer & Hematology Centers of Western Michigan, P.C. > Center for Molecular Medicine > ClinXus > Compassionate Care Protocol > Core Technology Alliance > Cornerstone University > Digestive Disease Institute > Grand Rapids Clinical Oncology Program > Grand Valley Medical Specialists > Grand Valley State University Good Manufacturing Practices Facility > Helen DeVos Children’s Hospital Pediatric Center Fellowship Program > Michigan Medical, P.C. > Spectrum Health > Saint Mary’s Health Care > West Michigan Center for Family Health > West Michigan Heart, P.C. > XB TransMed Solutions (XB-Biointegration Suite) > Holland, MI Hope College Kalamazoo, MI > Jasper Clinical Research & Development, Inc. > ProNAi Therapeutics > > > East Lansing, MI Michigan State University Lansing, MI Michigan Cancer Consortium Mt. Pleasant, MI Central Michigan University St. Joseph, MI > GeneGo, Inc. > Oncology Care Associates VARI Collaborations www.vai.org 25

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