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2013 Scientific Report

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VARI | 2013 VARI Seminar Series September 2011 Brooke McCartney, Carnegie Mellon University “At the intersection of Wnt signaling and cytoskeletal dynamics: a model systems approach to the study of the enigmatic tumor suppressor adenomatous polyposis coli” W. James Nelson, Stanford University “Evolution of epithelia and cadherin-based cell-cell adhesion” October Dan Klinosky, University of Michigan “If you only have time to attend one talk today on autophagy, this is the one” Robert Maki, Mount Sinai School of Medicine “Slugs, snails, and puppy dogs’ tails: what sarcomas are made of and how they are treated” November Dinshaw Patel, Memorial Sloan – Kettering Cancer Center “Structural biology of gene and epigenetic regulation” Andrew Dillin, Salk Institute for Biological Studies “Immortality, stem cells, and humoral signals of longevity” Alan Hall, Memorial Sloan – Kettering Cancer Center “Rho GTPases controlling epithelial morphogenesis and migration” Jennifer Cross, University of Virginia “The inflammatory cytokine MIF is an immune-modulating therapeutic target in tumor growth and metastasis” February 2012 March Shylam Biswal, Johns Hopkins University “Nrf2 as a target for cancer therapy” Regis J. O’Keefe, University of Rochester “Stem cell populations and their regulation in bone repair” Di Chen, Rush University Medical Center “TGF-b signaling and osteoarthritis” David Marc Virshup, Duke University “Regulating Wnts at the source — basic biology and potential therapy” April May Aik Choon Tan, University of Colorado “Translational bioinformatics: from bytes to bench and back” Vicki Rosen, Harvard University “BMP-2 links appositional bone growth and fracture repair” Phillip A. Sharp, Massachusetts Institutte of Technology Han-Mo Koo Memorial Lecture “Transcription and functions of microRNAs and other non-coding RNAs” Tom Shenk, Princeton University “Metabolomic analysis: fat management by human cytomegalovirus” 83

Van Andel Research Institute | Scientific Report June Richard Youle, National Institutes of Health “Molecular mechanisms of mitochondrial quality control through autophagy in Parkinson’s disease” July Collin Duckett, University of California, Los Angeles “IAP proteins in neoplasia and immunodeficiency” Anna Wu, David Geffen School of Medicine at UCLA “Engineered antibodies for immunoPET detection of cancer” August Hideho Okada, University of Pittsburgh “Type-1 polarizing vaccines for adult and pediatric gliomas” Sean Culter, University of California, Riverside “Chemical and genetic dissection of ABA signaling” Jennifer Gillette, University of New Mexico “Regulation of hematopoietic stem cell communication with the bone marrow niche” Bill Weis, Stanford University “The interplay of a-catenin and the actin cytoskeleton in cell adhesion and cell polarity” September Ralph J. DeBerardinis, M.D., Ph.D., University of Texas Southwestern Medical Center “Cancer metabolism — biological insights and translational opportunities” C. Titus Brown, Michigan State University “An efficient framework for throwing away most of your next-gen sequencing data” November Roger K. Sunahara, Univeristy of Michigan Medical School “Structural basis for G protein activation by GPCRs” John Kuriyan, University of California, Berkeley “Allosteric mechanisms in the activation of the EGF receptor” December Prasad Jallepalli, Memorial Sloan–Kettering Cancer Center “Surfing mitosis and cell division with chemical genetics” 84

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