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11 months ago

2002 Scientific Report

  • Text
  • Institute
  • Report
  • Tumors
  • Protein
  • Signaling
  • Michigan
  • Molecular
  • Proteins
  • Laboratory

Figure 1. Identification

Figure 1. Identification of gene expression biases on chromosome 8. A sliding window algorithm was used to scan for regional gene expression biases on chromosome 8. Regions of amplification (red) or deletion (green) can be detected by finding regions of expression biases that pass a significance threshold (in this example, the 95% confidence interval). Here, the portions of the p-arm of chromosome 8 above 95% are lost and the portions of the q-arm are gained. The 8p loss and 8q gain was confirmed by comparative genomic hybridization. External Collaborators Greg Wolffe, Grand Valley State University, Allendale, Michigan Publications Furge, Kyle A., Ramsi Haddad, Jeremy C. Miller, J. Schoumans, Brian B. Haab, Bin T. Teh, Lonson Barr, and Craig P. Webb. In press. Genomic profiling and cDNA microarray analysis of human colon adenocarcinoma and associated peritoneal metastasis reveals consistent cytogenetic and transcriptional aberrations associated with progression of multiple metastases. Applied Genomics and Proteomics. Furge, Kyle A., David Kiewlich, Phuong Le, My Nga Vo, Michel Faure, Anthony R. Howlett, Kenneth E. Lipson, George F. Vande Woude, and Craig P. Webb. 2001. Suppression of Rasmediated tumorigenicity and metastasis through inhibition of the Met receptor tyrosine kinase. Proceedings of the National Academy of Sciences U.S.A. 98(19): 10722-10727. Haddad, Ramsi, Kyle A. Furge, Jeremy C. Miller, Brian B. Haab, J. Schoumans, B.T. Teh, L. Barr, and Craig P. Webb. In press. Genomic profiling and cDNA microarray analysis of human colon adenocarcinoma and associated intraperitoneal metastases reveals consistent cytogenetic and transcriptional aberrations associated with progression of multiple metastases. Applied Genomics and Proteomics. Rhodes, Daniel R., Jeremy C. Miller, Brian B. Haab, and Kyle A. Furge. 2002. CIT: identification of differentially expressed clusters of genes from microarray data. Bioinformatics 18(1): 205–206. From left to right: Crawley, Furge, Dere 25

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