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2002 Scientific Report

  • Text
  • Institute
  • Report
  • Tumors
  • Protein
  • Signaling
  • Michigan
  • Molecular
  • Proteins
  • Laboratory

Title page photo:

Title page photo: HGF/SF-induced scattering of MDCK cells in vitro Shown are dog kidney–derived (MDCK) cells stained for DNA (using DAPI, green) and actin (phalloidinrhodamine, red). (Phalloidin is a protein that preferentially binds to actin and can be labeled with a fluorescent dye, here rhodamine.) Although DAPI is normally seen as blue, here the DAPI emission is placed in the green channel so that co-localization can be seen as yellow. These cells were treated with scatter factor (HGF/SF) to induce separation from their substrate and begin their migration/scattering. There is a large cluster of cells in the center and random, attenuated cells with longer cellular processes in the left center and upper right that are starting the scattering process. (Resau) © 2002 by the Van Andel Institute All rights reserved Van Andel Institute 333 Bostwick Avenue, N.E. Grand Rapids, Michigan 49503, U.S.A.

Contents Director’s Introduction . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 3 Laboratory Reports Laboratory of Cell Structure and Signal Integration . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 9 Arthur S. Alberts, Ph.D. Antibody Technology Laboratory . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 12 Brian Cao, M.D. Mass Spectrometry and Proteomics Laboratory . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 17 Gregory S. Cavey, B.S. Laboratory of Signal Regulation and Cancer . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 18 Sara A. Courtneidge, Ph.D. Developmental Cell Biology Laboratory . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 21 Nicholas S. Duesbery, Ph.D. Bioinformatics Core Program . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 24 Kyle Furge, Ph.D. Laboratory of DNA and Protein Microarray Technology . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 28 Brian B. Haab, Ph.D. Laboratory of Cancer Pharmacogenetics . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 31 Han-Mo Koo, Ph.D. Laboratory of Integrin Signaling and Tumorigenesis . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 33 Cindy K. Miranti, Ph.D. Analytical, Cellular, and Molecular Microscopy Laboratory . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 37 James H. Resau, Ph.D. Laboratory of Germline Modification . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 40 Pamela J. Swiatek, Ph.D. Laboratory of Cancer Genetics . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 43 Bin T. Teh, M.D., Ph.D. Laboratory of Molecular Oncology . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 45 George F. Vande Woude, Ph.D. Tumor Metastasis and Angiogenesis Laboratory . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 49 Craig P. Webb, Ph.D. iii

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