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2004 Scientific Report

Figure 2. Screen capture

Figure 2. Screen capture of the XenoBase integrated informatics database. This screen shows the hierarchical clustering of gene expression data collected from a series of human colorectal tumors and adjacent normal tissue. Two major sample groups were identified as abnormal (tumor samples labeled in red at top) and normal (blue labels) tissue. A single sample of “normal” tissue (green label) was found to have an abnormal gene expression signature. Further analysis of the histopathology of this tissue (insert) provided a diagnosis of ulcerative colitis, thereby explaining its abnormal genotype. External Collaborators Alan Campbell, Spectrum Health Oncology, Grand Rapids, Michigan Jack O’Donnell, Hematology Consultants of West Michigan, Grand Rapids Angela Tiberio, Spectrum Health Information Technology, Grand Rapids, Michigan Michael Warzynski, Spectrum Health, Flow Cytometry Lab, Grand Rapids, Michigan Pamela Kidd, Spectrum Health Pathology, Grand Rapids, Michigan Martin Luchtefeld, Digestive Disease Institute, Grand Rapids, Michigan Tom Monroe, Digestive Disease Institute, Grand Rapids, Michigan Pamela Grady, Digestive Disease Institute, Grand Rapids, Michigan Richard McNamara, West Michigan Heart, Grand Rapids, Michigan David Langholz, West Michigan Heart, Grand Rapids, Michigan Linda Pool, Spectrum Health, Grand Rapids, Michigan Deborah Ritz-Holland, Spectrum Health, Grand Rapids, Michigan Leon Oostendorp, Spectrum Health, Grand Rapids, Michigan Tony Foster, Spectrum Health, Grand Rapids, Michigan Eric Lester, Oncology Care Associates, St. Joseph, Michigan Lonson Barr, Michigan State University, Grand Rapids, Michigan Martin McMahon, University of California, San Francisco Harvey Pass, Karmanos Cancer Institute, Detroit, Michigan Keith Stewart, Princess Margaret Hospital, Toronto, Canada Allen Shoemaker, Medical Education and Research Center, Grand Rapids, Michigan Alan Davis, Michigan State University, East Lansing Annette Thelen, Michigan State University, East Lansing Samir Hanash, University of Michigan, Ann Arbor Gilbert Omenn, University of Michigan, Ann Arbor James Baker, University of Michigan, Ann Arbor 54

Recent Publications Bromberg-White, Jennifer L., Craig P. Webb, Veronique S. Patacsil, Cindy K. Miranti, Bart O. Williams, and Sheri L. Holmen. 2004. Delivery of short hairpin RNA sequences using a replication-competent avian retroviral vector. Journal of Virology 78(9): 4914–4916. Miller, J., J.L. Bromberg-White, K. DuBois, E. Eugster, S. Srikanth, R. Haddad, C. DeLeeuw, and C.P. Webb. 2003. Identification of metastatic gene targets in a murine model of ras-mediated fibrosarcomas. Applied Genomics and Proteomics 2(4): 253–265. Webb, Craig, Sarah Scollon, Jeremy Miller, and Bin Tean Teh. 2003. Gene expression profiling of endocrine tumors by microarray analysis. Current Opinion in Endocrinology and Diabetes 10(3): 162–167. Furge, Kyle A., Ramsi Haddad, Jeremy Miller, Brian B. Haab, Jacqueline Schoumans, Bin T. Teh, Lonson L. Barr, and Craig P. Webb. 2002. Genomic profiling and cDNA microarray analysis of human colon adenocarcinoma and associated peritoneal metastases reveals consistent cytogenetic and transcriptional aberrations associated with progression of multiple metastases. Applied Genomics and Proteomics 1(2): 123–134. Along wall, top to bottom: Ubels, Eugster, Srikanth, Sheehan, Bromberg- White; at left, from left to right: Webb, Benton, Monsma, Briegel 55

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