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2004 Scientific Report

VARI Seminar Series 2003

VARI Seminar Series 2003 January Shuichi Takayama, University of Michigan, Ann Arbor “Cell biology chips: technologies for cell sorting and subcellular signaling (EGF/integrin) studies” John Sacci, University of Maryland School of Medicine, Baltimore “Identifying gene expression in plasmodial liver-stage parasites: a needle in a haystack?” Jack Dixon, University of Michigan, Ann Arbor “Functional genomics: probing the intersection of bacterial pathogens with signal transduction pathways” Nita Maihle, Mayo Clinic, Rochester, Minnesota “Soluble ErbB/EGF receptors: form, function, and clinical utility” February Thomas Sturgill, University of Virginia, Charlottesville “Regulation, function, and structure of MAPKAP kinases” David Baltimore, California Institute of Technology, Pasadena “NF-κ as a neuronal intracellular messenger” Zhenping Zhuang, National Institutes of Health, Bethesda, Maryland “Integration of tissue microdissection into genomics and proteomics: a new approach to study disease” March Richard Vile, Mayo Clinic, Rochester, Minnesota “Gene and immunotherapy for cancer: making the tumor a dangerous place to die” Marc Lippman, University of Michigan, Ann Arbor “Inducing apoptosis as a new approach to cancer therapy” George Prendergast, Thomas Jefferson University, Philadelphia, Pennsylvania “Novel mechanisms of cancer suppression and cell suicide” April Chung Lee, Northwestern University, Evanston, Illinois “TGF-β-based gene therapy for cancer” Fred Chang, Columbia University, New York City “Microtubules and formins in regulation of cell polarity” Max Wicha, University of Michigan, Ann Arbor “Stem cells in the normal and cancerous breast” 83

May Michael White, University of Texas Southwestern Medical Center, Dallas “Molecular linchpins in the tumorigenic platform” Maxwell Gottesman, Columbia University, New York City “AKAP 121 and cAMP-dependent mRNA translocation to mitochondria” Alfred Singer and Dinah Singer, National Cancer Institute, Bethesda, Maryland “Regulation of MHC class I gene expression” (D.S.) “How a bipotential cell in the thymus determines its appropriate cell fate” (A.S.) Larry Einhorn, Indiana University, Bloomington The Daniel Nathans Lecture: “Testicular cancer: a model for a curable neoplasm” “Curing cancer: unrealistic expectations versus promises fulfilled” (lay audience) June Stuart Yuspa, National Cancer Institute, Bethesda, Maryland “mtCLIC/CLIC4, a p53- and TNF-α-regulated chloride channel protein, is a novel molecular target involved in apoptosis, growth arrest, and cancer pathogenesis” James Baker, University of Michigan, Ann Arbor “Nanotherapeutics for cancer” Richard Gaynor, Eli Lilly, Indianapolis, Indiana “Regulation of the NK-κB pathway” Karen Antman, Columbia University, New York City “Translational studies in sarcomas, an understudied malignancy” July Norman Coleman, National Cancer Institute, Bethesda, Maryland “Radiation oncology in the 21st century: technical advancements and biological concepts” Alfred Brown, Yale University, New Haven, Connecticut “The university discovery engine: turning academic research into public benefit” Bruce Kemp, St. Vincent’s Institute of Medical Research, Melbourne, Australia “AMPK mediating the health benefits of exercise and diet” Jas Lang, Ohio State University, Columbus “Molecular genetics of head and neck cancer” August Evan Keller, University of Michigan, Ann Arbor “The biology of prostate cancer skeletal metastases” Mario Capecchi, University of Utah, Salt Lake City “Gene targeting into the 21st century: mouse models of human disease from cancer to psychiatric disorders” 84

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