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2006 Scientific Report

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Van Andel Research

Van Andel Research Institute | Scientific Report ii Table of Contents

VARI | 2006 Director’s Introduction 1 George F. Vande Woude, Ph.D. Laboratory Reports 5 Arthur S. Alberts, Ph.D. Cell Structure and Signal Integration 6 Brian Cao, M.D. Antibody Technology 10 Gregory S. Cavey, B.S. Mass Spectrometry and Proteomics 14 Nicholas S. Duesbery, Ph.D. Cancer and Developmental Cell Biology 17 Bryn Eagleson, A.A., RLATG Vivarium and Transgenics 22 Kyle A. Furge, Ph.D. Computational Biology 24 Brian B. Haab, Ph.D. Cancer Immunodiagnostics 27 Rick Hay, Ph.D., M.D., F.A.H.A. Noninvasive Imaging and Radiation Biology 34 iii Sheri L. Holmen, Ph.D. Molecular Medicine and Virology 38 Cindy K. Miranti, Ph.D. Integrin Signaling and Tumorigenesis 42 James H. Resau, Ph.D. Division of Quantitative Sciences Analytical, Cellular, and Molecular Microscopy Microarray Technology 47 Pamela J. Swiatek, Ph.D., M.B.A. Germline Modification 52 Bin T. Teh, M.D., Ph.D. Cancer Genetics 58 George F. Vande Woude, Ph.D. Molecular Oncology 63 Craig P. Webb, Ph.D. Tumor Metastasis and Angiogenesis 68 Michael Weinreich, Ph.D. Chromosome Replication 73 Bart O. Williams, Ph.D. Cell Signaling and Carcinogenesis 77 H. Eric Xu, Ph.D. Structural Sciences 84 Nian Zhang, Ph.D. Mammalian Developmental Genetics 89

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