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2007 Annual Report

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Grants Awarded to VARI

Grants Awarded to VARI Researchers - 2007 One of the indicators of the quality and impact of the research conducted at Van Andel Institute is the success of our researchers in competing for grant funding. In 2007, researchers were awarded highly competitive grants and renewals for grants from organizations such as the National Institutes of Health (NIH), the Department of Defense, the National Foundation of Cancer Research, the American Cancer Society, and the American Heart Association. Sponsor > MEDC/Department of Treasury > MEDC/21st Century Jobs Fund > NIH/National Heart, Lung & Blood Institute > > NIH/National Institute of Arthritis & Musculoskeletal & Skin Diseases - R01 NIH/National Institute of Diabetes & Digestive & Kidney Diseases - R01 NIH/National Institute of Allergy & Infectious Diseases NIH/National Institute of Diabetes & Digestive & Kidney Diseases - R01 NIH/National Cancer Institute - R01 + Minority Trainee Supplement Gerber Foundation American Cancer Society American Cancer Society American Cancer Society > Department of Defense > Department of Defense > Department of Defense Project Title Creation of Good Manufacturing Practicies (GMP) Facility Development of an Innovative Clinical Research Alliance Structural and Functional Studies of Nuclear Receptor PPSRgamma Analyzing the Role of Wnt Signaling in Bone Development Stucture and Functions of Steroid Hormone Receptors Chromatin and Coactivators in HSV-1 Gene Regulation Structural Genomics of Orphan Nuclear Receptors MEK Signaling in Sarcoma Growth and Vascularization Gene Expression Profiling in Newborns with Congenital Chromosomal Abnormalities Diaphanous-Related Formins in Myelodysplasia Integrin and RTK Signaling and Crosstalk in Prostate Epithelial Cells Identifying Small Molecule Inhibitors of Cdc7 Kinase A Role for Formin-Mediated Cytoskeletal Regulation in the Mesenchymal-Amoeboid-Transition in Breast Cancer Development Met Signaling Promotes Mammary Stem Cell Proliferation Intravital Imaging of Developing Breast Cancer Lesion of Defined Genomic Profile in a Mouse FY 2007 Total ,000,000 4,800 5,000 0,471 9,681 4,000 8,317 6,459 5,415 0,000 0,000 0,000 6,500 6,500 6,500 Van Andel Research Institute

indicates new grants awarded in fiscal year 2007 Sponsor Project Title FY 2007 Total > Breast Cancer Research Foundation Novel Approach for Breast Molecular Imaging and Therapy using Met Tyrosine Kinase as a Target 5,000 NIH/National Cancer Institute via University of Pittsburg - U01 Multiplexed Serum Biomarkers for Pancreatic Cancer ,065 MEDC/MTTC via University of Michigan Proteomics Alliance for Cancer Research ,896 MEDC/MTTC via University of Michigan Proteomics Alliance for Cancer Research ,790 > Genentech, Inc. Growth Curve of H1650, H1666, and SK-MES-1 in HGF/SF-SCID Mice Xenograft Study ,502 > National Foundation of Cancer Research Guided Molecular Therapeutic Studies of Kidney Cancer ,000 NIH/National Institute of Child Health & Human Development via Michigan State University - T32 Training Program in Perinatal Epidemiology ,326 > > > > NIH/National Cancer Insitute via University of Michigan - P50 Spectrum Health VHL Family Alliance Fund for Cancer Research Knights Templar Eye Foundation NIH/National Cancer Insitute/SAIC- Frederick, Inc. via University of Michigan American Heart Association In-Vivo Imaging of Neoplasia P13K-m TOR Pathway Bioinformatics and Therapy in Colorectal Cancer Multigenic Process in VHL-Related and Sporadic Clear Cell Renal Cell Carcinoma (ccRCC): Characterization of a Novel VHL-Synergistic ccRCC-Related Gene in Chromosone 5q The Role of MAPK Signaling in Vascular Development in the Eye Proteomic Technologies Easter Research Resources Consortium Role of Transcriptional Coactivators in Herpes Simplex Virus Gene Expression ,530 ,000 ,000 ,000 ,665 ,000 VARI2007 Grants > McCarthy (J.P.) Fund/Community Foundation of Southeast Michigan Defective mDia1/DIAPH1 Expression in Myelodysplastic Syndromes ,000 > Orthopaedic Research and Education Foundation Differential Growth and Metastasis of Human Osteosarcoma Xenografts in a Human HGF/SF Transgenic Mouse Model with Multi- Modality Imaging Assessment ,000 21

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