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2007 Scientific Report

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VARI | 2007 Evaluating the blood supply of cancer with ultrasound. 45 Human glioblastoma (brain cancer) cells were grown as a tumor beneath the skin of a laboratory mouse. Small bubbles about the size of individual blood cells were then injected into the mouse’s bloodstream. During the next few minutes the tumor was imaged by ultrasound, using a device similar to sonar. Echoes from the bubbles, shown in green, depict complex branching patterns of tiny blood vessels growing around and within the tumor to supply it with nutrients and oxygen. We are using the ultrasound technique to monitor how new types of anticancer medicine change the abundance and branching of tumor blood vessels in mice, with the hope of applying this technology in the near future to patients with cancer.

Van Andel Research Institute | Scientific Report James H. Resau, Ph.D. Division of Quantitative Sciences Laboratory of Analytical, Cellular, and Molecular Microscopy Laboratory of Microarray Technology Laboratory of Molecular Epidemiology 46 Dr. Resau received his Ph.D. from the University of Maryland School of Medicine in 1985. He has been involved in clinical and basic science imaging and pathology-related research since 1972. Between 1968 and 1994, he was in the U.S. Army (active duty and reserve assignments) and served in Vietnam. From 1985 until 1992, Dr. Resau was a tenured faculty member at the University of Maryland School of Medicine, Department of Pathology. Dr. Resau was the Director of the Analytical, Cellular and Molecular Microscopy Laboratory in the Advanced BioScience Laboratories–Basic Research Program at the National Cancer Institute, Frederick Cancer Research and Development Center, Maryland, from 1992 to 1999. He joined VARI as a Special Program Senior Scientific Investigator in June 1999 and in 2003 was promoted to Deputy Director. In 2004, Dr. Resau assumed as well the direction of the Laboratory of Microarray Technology to consolidate the imaging and quantification of clinical samples in a CLIA-type research laboratory program. In 2005, Dr. Resau was made the Division Director of the quantitative laboratories (pathology-histology, microarray, proteomics, epidemiology, and bioinformatics), and in 2006 he was promoted to Distinguished Scientific Investigator. Staff Laboratory Staff Eric Kort, M.D. Brendan Looyenga, Ph.D. Bree Berghuis, B.S., HTL (ASCP), QIHC Eric Hudson, B.S. Paul Norton, B.S. Ken Olinger, B.S. David Satterthwaite, B.S. Kristin VandenBeldt, B.S. JC Goolsby Students Pete Haak, B.S. Alicia Coleman Kate Jackson Wei Luo, B.A. Nick Miltgen Kara Myslivec Sara Ramirez Jourdan Stuart Mohan Thapa, M.S. Huong Tran Grant Van Eerden Visiting Scientist Yair Andegeko

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