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2007 Scientific Report

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VARI | 2007 Table of Contents Director’s Introduction 1 George F. Vande Woude, Ph.D. Laboratory Reports 5 Arthur S. Alberts, Ph.D. Cell Structure and Signal Integration 6 Brian Cao, M.D. Antibody Technology 10 Gregory S. Cavey, B.S. Mass Spectrometry and Proteomics 13 Nicholas S. Duesbery, Ph.D. Cancer and Developmental Cell Biology 18 Bryn Eagleson, B.S., RLATG Vivarium and Transgenics 21 Kyle A. Furge, Ph.D. Computational Biology 23 Brian B. Haab, Ph.D. Cancer Immunodiagnostics 26 Rick Hay, Ph.D., M.D., F.A.H.A. Noninvasive Imaging and Radiation Biology Office of Translational Programs 31 Jeffrey P. MacKeigan, Ph.D. Systems Biology 35 Cindy K. Miranti, Ph.D. Integrin Signaling and Tumorigenesis 39 James H. Resau, Ph.D. Division of Quantitative Sciences Analytical, Cellular, and Molecular Microscopy Microarray Technology Molecular Epidemiology 46 Pamela J. Swiatek, Ph.D., M.B.A. Germline Modification and Cytogenetics 51 Bin T. Teh, M.D., Ph.D. Cancer Genetics 55 Steven J. Triezenberg, Ph.D. Transcriptional Regulation 62 George F. Vande Woude, Ph.D. Molecular Oncology 66 Craig P. Webb, Ph.D. Program for Translational Medicine Tumor Metastasis and Angiogenesis 70 Michael Weinreich, Ph.D. Chromosome Replication 74 Bart O. Williams, Ph.D. Cell Signaling and Carcinogenesis 78 H. Eric Xu, Ph.D. Structural Sciences 84 iii

Van Andel Research Institute | Scientific Report 2006 Van Andel Research Institute Symposium 88 Winning the War against Cancer: From Genomics to Bedside and Back Daniel Nathans Memorial Award 94 Tony Hunter, Ph.D., and Tony Pawson, Ph.D. Postdoctoral Fellowship Program 96 List of Fellows Student Programs 98 Grand Rapids Area Pre-College Engineering Program Summer Student Internship Program Han-Mo Koo Memorial Seminar Series 102 2006 | 2007 Seminars iv Van Andel Research Institute Organization 107 Boards Office of the Director VAI Administrative Organization

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