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2007 Scientific Report

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VARI |

VARI | 2007 From left: Gao, Thompson, Xie, Graveel, Kaufman, Vande Woude, Staal, Bassett, Haak, Nelson, DeGroot, Su, Zhang Recent Publications Lindemann, K.K., J. Resau, J. Nährig, E. Kort, B. Leeser, K. Anneke, A. Welk, J. Schäfer, G.F. Vande Woude, E. Lengyel, and N. Harbeck. In press. Differential expression of c-Met, its ligand HGF/SF, and HER2/neu in DCIS and adjacent normal breast tissue. Histopathology. 69 Zhang, Y.W., and G.F. Vande Woude. In press. Mig-6, signal transduction, stress response, and cancer. Cell Cycle. Sawada, Kenjiro, A. Reza Radjabi, Nariyoshi Shinomiya, Emily Kistner, Hilary Kenny, Amy R. Becker, Muge A. Turkyilmaz, Ravi Salgia, S. Diane Yamada, George F. Vande Woude, Maria S. Tretiakova, and Ernst Lengyel. 2007. c-Met overexpression is a prognostic factor in ovarian cancer and an effective target for inhibition of peritoneal dissemination and invasion. Cancer Research 67(4): 1670–1679. Zhang, Y.-W., B. Staal, Y. Su, P. Swiatek, P. Zhao, B. Cao, J. Resau, R. Sigler, R. Bronson, and G.F. Vande Woude. 2007. Evidence that MIG-6 is a tumor-suppressor gene. Oncogene 26(2): 269–276. Gherardi, Ermanno, Sara Sandin, Maxim V. Petoukhov, John Finch, Mark E. Youles, Lars-Göran Öfverstedt, Ricardo N. Miguel, Tom L. Blundell, George F. Vande Woude, Ulf Skoglund, and Dmitri I. Svergun. 2006. Structural basis of hepatocyte growth factor/scatter factor and MET signalling. Proceedings of the National Academy of Sciences U.S.A. 103(11): 4046–4051. Lee, Jae-Ho, Chong Feng Gao, Chong Chou Lee, Myung Deok Kim, and George F. Vande Woude. 2006. An alternatively spliced form of Met receptor is tumorigenic. Experimental and Molecular Medicine 38(5): 565–573. Moshitch-Moshkovitz, Sharon, Galia Tsarfaty, Dafna W. Kaufman, Gideon Y. Stein, Keren Shichrur, Eddy Solomon, Robert H. Sigler, James H. Resau, George F. Vande Woude, and Ilan Tsarfaty. 2006. In vivo direct molecular imaging of early tumorigenesis and malignant progression induced by transgenic expression of GFP-Met. Neoplasia 8(5): 353–363. Tsarfaty, Galia, Gideon Y. Stein, Sharon Moshitch-Moshkovitz, Dafna W. Kaufman, Brian Cao, James H. Resau, George F. Vande Woude, and Ilan Tsarfaty. 2006. HGF/SF increases tumor blood volume: a novel tool for the in vivo functional molecular imaging of Met. Neoplasia 8(5): 344–352.

Van Andel Research Institute | Scientific Report Craig P. Webb, Ph.D. Program for Translational Medicine Laboratory of Tumor Metastasis and Angiogenesis 70 Dr. Webb received his Ph.D. in cell biology from the University of East Anglia, England, in 1995. He then served as a postdoctoral fellow in the laboratory of George Vande Woude in the Molecular Oncology Section of the Advanced BioScience Laboratories–Basic Research Program at the National Cancer Institute, Frederick Cancer Research and Development Center, Maryland (1995–1999). Dr. Webb joined VARI as a Scientific Investigator in October 1999. Staff Laboratory Staff Students Visiting Scentists Visiting Scientists Student David Cherba, Ph.D. Jessica Hessler, PhD. Jeremy Miller, Ph.D. David Monsma, Ph.D. Emily Eugster, M.S. Sujata Srikanth, M.Phil. Dawna Dylewski, B.S. Brian Hillary, B.A. Marcy Ross, B.S. Stephanie Scott, B.S. Katherine Koehler Philip Grimley, M.D. David Reinhold, Ph.D. Guenther Tusch, Ph.D. Molly Dobb

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