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2007 Scientific Report

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VARI |

VARI | 2007 From left, standing: Williams, Robinson; seated: Zylstra, Lindvall Recent Publications Lindvall, C., W. Bu, B.O. Williams, and Y. Li. In press. Wnt signaling, stem cells, and the cellular origin of breast cancer. Stem Cell Reviews. Wu, R., N.D. Handrix, R. Kuick, Y. Zhai, D.R. Schwartz, A. Akyol, S. Hanash, D. Misek, H. Katabuchi, B.O. Williams, E.R. Fearon, and K.R. Cho. In press. Mouse model of human endometroid adenocarcinoma based on somatic defects in the Wnt β-catenin and PI3K/Pten signaling pathways. Cancer Cell. 81 Young, J.J., J.L. Bromberg-White, C.R. Zylstra, J. Church, E. Boguslawski, J. Resau, B.O. Williams, and N. Duesbery. In press. LRP5 and LRP6 are not required for protective antigen-mediated internalization or lethality of anthrax lethal toxin. PLoS Pathogens. Bruxvoort, Katia J., Holli M. Charbonneau, Troy A. Giambernardi, James C. Goolsby, Chao-Nan Qian, Cassandra R. Zylstra, Daniel R. Robinson, Pradip Roy-Burman, Aubie K. Shaw, Bree D. Buckner-Berghuis, Robert E. Sigler, James H. Resau, Ruth Sullivan, Wade Bushman, and Bart O. Williams. 2007. Inactivation of Apc in the mouse prostate causes prostate carcinoma. Cancer Research 67(6): 2490–2496. Liu, X., K.M. Bruxvoort, Cassandra R. Zylstra, J. Liu, R. Cichowski, Marie-Claude Faugere, Mary L. Bouxsein, C. Wan, Bart O. Williams, and Thomas L. Clemens. 2007. Lifelong accumulation of bone in mice lacking Pten in osteoblasts. Proceedings of the National Academy of Sciences U.S.A. 104(7): 2259–2264. Inoki, Ken, Hongjiao Ouyang, Tianqing Zhu, Charlotta Lindvall, Yian Wang, Xiaojie Zhang, Qian Yang, Christina Bennett, Yoku Harada, Kryn Stankunas, Cun-yu Wang, Xi He, Ormond A. MacDougald, Ming You, Bart O. Williams, and Kun-Liang Guan. 2006. TSC2 integrates Wnt and energy signals via a coordinated phosphorylation by AMPK and GSK3 to regulate cell growth. Cell 126(5): 955–968. Lindvall, Charlotta, Nicole C. Evans, Cassandra R. Zylstra, Yi Li, Caroline M. Alexander, and Bart O. Williams. 2006. The Wnt signaling receptor LRP5 is required for mammary ductal stem cell activity and Wnt1-induced tumorigenesis. Journal of Biological Chemistry 281(46): 35081–35087. Zhang, Chun, Dong Kong, Min-Han Tan, Donald L. Pappas, Jr., Peng-Fei Wang, Jindong Chen, Leslie Farber, Nian Zhang, Han-Mo Koo, Michael Weinreich, Bart O. Williams, and Bin Tean Teh. 2006. Parafibromin inhibits cancer cell growth and causes G1 phase arrest. Biochemical and Biophysical Research Communications 350(1): 17–24.

Van Andel Research Institute | Scientific Report 82 Photo taken by Veronique Schulz of the Mirant lab.

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