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2008 Scientific Report

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Van Andel Research

Van Andel Research Institute | Scientific Report Title page illustration: The glucocorticoid receptor. The figure represents the crystal structure of the glucocorticoid receptor (GR) bound to deacylcortivazol, which is a highly potent ligand against childhood leukemia. The GR protein chain is shown as ribbons, with helix 1 in blue and the coactivator helix in red. The deacylcortivazol molecule is shown within the GR structure in green, with the GR ligand-binding pocket shown by the yellow mesh. Structure by the Xu lab. Published June 2008. Copyright 2008 by the Van Andel Institute; all rights reserved. Van Andel Institute, 333 Bostwick Avenue, N.E., Grand Rapids, Michigan 49503, U.S.A. ii

VARI | 2008 Director’s Introduction 1 George F. Vande Woude, Ph.D. Laboratory Reports 5 Arthur S. Alberts, Ph.D. Cell Structure and Signal Integration 6 Brian Cao, M.D. Antibody Technology 9 Gregory S. Cavey, B.S. Mass Spectrometry and Proteomics 12 Nicholas S. Duesbery, Ph.D. Cancer and Developmental Cell Biology 15 Bryn Eagleson, B.S., RLATG Vivarium and Transgenics Program 20 Kyle A. Furge, Ph.D. Computational Biology 22 Brian B. Haab, Ph.D. Cancer Immunodiagnostics 25 Table of Contents Rick Hay, Ph.D., M.D., F.A.H.A. Noninvasive Imaging and Radiation Biology Office of Translational Programs 29 Jeffrey P. MacKeigan, Ph.D. Systems Biology 34 Cindy K. Miranti, Ph.D. Integrin Signaling and Tumorigenesis 38 James H. Resau, Ph.D. Division of Quantitative Sciences Analytical, Cellular, and Molecular Microscopy Microarray Technology Molecular Epidemiology 42 Pamela J. Swiatek, Ph.D., M.B.A. Germline Modification and Cytogenetics 46 Bin T. Teh, M.D., Ph.D. Cancer Genetics 51 Steven J. Triezenberg, Ph.D. Transcriptional Regulation 55 George F. Vande Woude, Ph.D. Molecular Oncology 59 Craig P. Webb, Ph.D. Program for Translational Medicine Tumor Metastasis and Angiogenesis 63 Michael Weinreich, Ph.D. Chromosome Replication 68 Bart O. Williams, Ph.D. Cell Signaling and Carcinogenesis 72 H. Eric Xu, Ph.D. Structural Sciences 76 iii

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