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2009 Scientific Report

  • Text
  • Institute
  • Scientific
  • Molecular
  • Laboratory
  • Tumor
  • Signaling
  • Michigan
  • Biology

Why the Translational

Why the Translational Genomics Research Institute? Translational Genomics Research Institute Phoenix, Arizona TGen presents numerous opportunities for innovative scientists and physicians at various career levels. Our faculty have access to the latest technologies – often serving as a test site for new technology platforms – for studying genes and proteins, including advances in next-generation sequencing techniques as applied to medical benefit. In addition to TGen’s research into the genetic basis of cancer, neurological conditions and metabolic disorders, TGen also plays a role in national security and bio-defense at TGen North, our facility in Flagstaff, Arizona, under the leadership of internationally recognized pathogen expert, Dr. Paul Keim. TGen’s Clinical Research Service (TCRS) at Scottsdale Healthcare provides TGen with a clinical research site. Dr. Daniel Von Hoff, TGen’s Physician-in-Chief, also serves as Chief Scientific Officer for TCRS, where clinicians focus on clinical trials with targeted agents and genomicsbased individualized therapy. TCRS, with an initial focus on cancer, allows the unique opportunity for TGen to transition its laboratory-based research to patient care centered on individualized therapy. With nearly 25 active clinical trials for advanced and/or rare cancers, TCRS is one of the nation’s leading centers for PhaseII oncology trials. TGen’s innovations have resulted in several partnerships and non-profit as well as for-profit spin-offs involving: physician resources, molecular profiling, business consulting, venture capital, drug development and clinical trials. In partnership with ASU’s Biodesign Institute, Seattle’s Fred Hutchinson Cancer Research Institute and Seattle’s Institute for Systems Biology, TGen most recently established the Partnership for Personalized Medicine. The goal of TGen’s education and outreach programs is to increase the working knowledge of genomics within the community at large and to help educate, train and excite the next generation of scientists. The Institute’s roleineducationcontinuouslyevolves, and currently includes programs for high school, undergraduate and graduate students, pre- and postdoctoral students, and fellowships. “There are a lot of exceptionally talented scientists at TGen; there are particular strengths in translational research and in equipment related to that strength. This includes the infrastructure to perform and organize clinical trials.’’ — Dr. Bart Williams Head of VARI’s Laboratory of Cell Signaling and Carcinogenesis, following his visits to TGen Van Andel Research Institute ® 333 Bostwick Ave NE Grand Rapids, MI 49503 (616) 234 5000 | 445 N 5th Street Phoenix, AZ 85004 (602) 343 8400 |

VARI | 2009 Laboratory Reports 7

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