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2009 Scientific Report

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Van Andel Research

Van Andel Research Institute | Scientific Report Copyright 2009 by the Van Andel Institute; all rights reserved. Van Andel Institute, 333 Bostwick Avenue, N.E., Grand Rapids, Michigan 49503, U.S.A. ii

VARI | 2009 Director’s Introduction 1 George F. Vande Woude, Ph.D. Laboratory Reports 7 Arthur S. Alberts, Ph.D. Cell Structure and Signal Integration 8 Brian Cao, M.D. Antibody Technology 11 Gregory S. Cavey, B.S. Mass Spectrometry and Proteomics 14 Nicholas S. Duesbery, Ph.D. Cancer and Developmental Cell Biology 17 Bryn Eagleson, B.S., RLATG Vivarium and Transgenics Program 20 Kyle A. Furge, Ph.D. Computational Biology 23 Brian B. Haab, Ph.D. Cancer Immunodiagnostics 26 Table of Contents Jeffrey P. MacKeigan, Ph.D. Systems Biology 30 Cindy K. Miranti, Ph.D. Integrin Signaling and Tumorigenesis 35 James H. Resau, Ph.D. Division of Quantitative Sciences Analytical, Cellular, and Molecular Microscopy Microarray Technology Molecular Epidemiology 39 Pamela J. Swiatek, Ph.D., M.B.A. Germline Modification and Cytogenetics 43 Bin T. Teh, M.D., Ph.D. Cancer Genetics 47 Steven J. Triezenberg, Ph.D. Transcriptional Regulation 51 George F. Vande Woude, Ph.D. Molecular Oncology 55 Craig P. Webb, Ph.D. Program for Translational Medicine 59 Michael Weinreich, Ph.D. Chromosome Replication 64 Bart O. Williams, Ph.D. Cell Signaling and Carcinogenesis 68 H. Eric Xu, Ph.D. Structural Sciences 72 iii

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