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2009 Scientific Report

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Van Andel Research

Van Andel Research Institute | Scientific Report Quantitative mass spectrometry: it’s all in the peaks! Liquid chromatography-mass spectrometry (LC-MS) is being widely used to identify, quantify, and compare hundreds, even thousands of proteins in diseased versus normal samples, with a goal of better understanding cancer systems biology and finding biomarkers that will improve clinical decision making. Shown in various colors are sections of mass spectra from LC-MS chromatograms of cachexia, metastatic, and non-metastatic disease models, demonstrating the fine detail of protein characterization that can be obtained from complex protein samples. Graphs courtesy of Greg Cavey. 34

VARI | 2009 Cindy K. Miranti, Ph.D. Laboratory of Integrin Signaling and Tumorigenesis Dr. Miranti received her M.S. in microbiology from Colorado State University in 1982 and her Ph.D. in biochemistry from Harvard Medical School in 1995. She was a postdoctoral fellow in the laboratory of Joan Brugge at ARIAD Pharmaceuticals, Cambridge, Massachusetts, from 1995 to 1997 and in the Department of Cell Biology at Harvard Medical School from 1997 to 2000. Dr. Miranti joined VARI as a Scientific Investigator in January 2000. She is also an Adjunct Assistant Professor in the Department of Physiology at Michigan State University and an Assistant Professor in the Van Andel Education Institute. Staff Electa Park, Ph.D. Kristin Saari, M.S. Lia Tesfay, M.S. Veronique Schulz, B.A. Students Jelani Zarif, M.S. Laura Lamb, B.S. Susan Spotts, B.S. Erica Bechtel Eric Graf Fraser Holleywood Gary Rajah, Jr. 35

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