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2013 Scientific Report

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VARI | 2013 Research Interests The Small-Animal Imaging Facility provides novel imaging and image analysis tools for use with biology specimens and small animals. Our instruments include digital X-ray, high-resolution microCT, microSPECT/CT, microPET/CT, micro-ultrasound, and optical imaging. Our research focuses on the development of new preclinical imaging technologies that can offer significant anatomic and functional information to biomedical investigators. The Laboratory of Translational Imaging aims at developing imaging technologies capable of monitoring organ/tissue activity at the molecular level. We intend these developments to be highly translatable into clinical use, especially for tumor early detection and staging. Combining tracer development, imaging analysis, and genomic information, we are dedicated to collecting medically useful information through novel, non-invasive imaging technologies that will advance the goal of personalized precision medicine. Recent Publications Flaten, Gøril Eide, Ting-Tung Chang, William T. Phillips, Martin Brandl, Ande Bao, and Beth Goins. In press. Liposomal formulations of poorly soluble camptothecin: drug retention and biodistribution. Journal of Liposome Research. Figure 1 Figure 1. Three-dimensional imaging of a kidney cyst in vivo using contrastenhanced computed tomography (CT). 15

Nicholas S. Duesbery, Ph.D. Laboratory of Cancer and Developmental Cell Biology Dr. Duesbery received a B.Sc. (Hon.) in biology (1987) from Queen’s University, Canada, and both his M.Sc. (1990) and Ph.D. (1996) degrees in zoology from the University of Toronto under the supervision of Yoshio Masui. Before his appointment at VARI in 1999, he was a postdoctoral fellow in George Vande Woude’s laboratory at the National Cancer Institute, Frederick Cancer Research and Development Center, Maryland. Dr. Duesbery was promoted to Associate Professor in 2006, and he chairs VARI’s Council for Research Affairs. From left: Duesbery, Boguslawski, Bromberg-White, Lewis, Kuk, Andersen, Bhattacharya, Naidu Staff Nicholas Andersen, Ph.D. Poulomi Bhattacharya, Ph.D. Elissa Boguslawski Jenn Bromberg-White, Ph.D. Kara Kits, Ph.D. Diana Lewis, A.S. Students Cynthia Kuk, B.S. Agni Naidu, B.S., B.A. Adjunct Faculty Christopher Chambers, M.D., Ph.D. Lou Glazer, M.D. Barbara Kitchell, D.V.M., Ph.D., DACVIM 16

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