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2013 Scientific Report

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VARI |

VARI | 2013 Figure 1 Figure 1: Dbf4 is a molecular scaffold for three protein kinases and controls genome integrity at multiple levels. Dbf4 binds Cdc7 kinase through C-terminal sequences to initiate DNA replication. Dbf4 binds Cdc5 (Polo kinase) and Rad53 (Chk2 kinase) through adjacent N-terminal sequences to control cell cycle progression in response to spindle and/or genomic stresses. Recent Publications Chang, FuJung, Caitlin D. May, Timothy Hoggard, Jeremy Miller, Catherine A. Fox, and Michael Weinreich. 2011. Highresolution analysis of four efficient yeast replication origins reveals new insights into the ORC and putative MCM binding elements. Nucleic Acids Research 39(15): 6523–6535. 65

Bart O. Williams, Ph.D. Laboratory of Cell Signaling and Carcinogenesis Dr. Williams received his Ph.D. in biology from Massachusetts Institute of Technology in 1996 under the supervision of Tyler Jacks. He joined VARI in July 1999 and was promoted to Associate Professor in 2006. Prior to his recruitment, he was a postdoctoral fellow at the National Institutes of Health in the laboratory of Harold Varmus. From left: Valkenburg, Maupin, Zahatnansky, Van Wieren, Williams, Burgers, Haider, Joiner, Diegel, Lewis, Droscha Staff Students Adjunct Faculty Travis Burgers, Ph.D. Cassie Diegel, B.S. Danese Joiner, Ph.D. Diana Lewis, A.S. Emily Van Wieren, B.S. Juraj Zahatnansky, M.D. Alex Zhong, Ph.D. Casey Droscha, B.S. Rida Haider, M.S. Kevin Maupin, B.S. Ken Valkenberg, B.S. Clifford Jones, M.D. Madhuri Kakarala, M.D., Ph.D. Charlotta Lindvall, M.D., Ph.D. Debra Sietsema, Ph.D., RN 66

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