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2015 Scientific Report

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Van Andel Research

Van Andel Research Institute | Scientific Report 2015 4

LABORATORY REPORTS Center for Cancer and Cell Biology Bart O. Williams, Ph.D. Director The Center’s scientists study the basic mechanisms and molecular biology of cancer and other diseases, with the goal of developing better diagnostics and therapies. The confocal microscopy image at left shows staining that characterizes cellular and molecular heterogeneity. miRNA and protein biomarkers are shown in a breast cancer tissue core from an ER-negative tissue microarray using a fully automated 6-plex ISH/IHC assay. This innovative technology was recently implemented as a collaborative project between VARI research labs and the pathology core. Cytokeratin 19 (orange) highlights cancer cells, and miR-21 (green) marks tumor-associated fibroblasts. U6 snRNA (red) is expressed in many nuclei, and collagen I (light blue) highlights the tissue vasculature. Image by Tim Feinstein and Lorenzo Sempere; sample provided by Galen Hostetter. 5

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