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2015 Scientific Report

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Van Andel Research

Van Andel Research Institute | Scientific Report 2015 ii ii

Director's Introduction 1 Laboratory Reports Center for Cancer and Cell Biology Arthur S. Alberts, Ph.D. Laboratory of Cell Structure and Signal Integration 6 Nicholas S. Duesbery, Ph.D. Laboratory of Cancer and Developmental Cell Biology 8 Carrie R. Graveel, Ph.D. Breast Cancer Signaling and Therapeutics 10 Brian B. Haab, Ph.D. Laboratory of Cancer Immunodiagnostics 12 Yuanzheng (Ajian) He, Ph.D. Structural Science and Molecular Signaling 15 Xiaohong Li, Ph.D. Laboratory of Tumor Microenvironment and Metastasis 16 Jeffrey P. MacKeigan, Ph.D. Laboratory of Systems Biology 18 Table of Contents Karsten Melcher, Ph.D. Laboratory of Structural Biology and Biochemistry 22 Cindy K. Miranti, Ph.D. Laboratory of Integrin Signaling and Tumorigenesis 25 Lorenzo F. Sempere, Ph.D. Laboratory of microRNA Diagnostics and Therapeutics 28 Matthew Steensma, M.D. Laboratory of Musculoskeletal Oncology 30 George F. Vande Woude, Ph.D. Laboratory of Molecular Oncology 32 Bart O. Williams, Ph.D. Laboratory of Cell Signaling and Carcinogenesis 35 Ning Wu, Ph.D. Laboratory of Cancer Signaling and Metabolism 38 Qian Xie, M.D., Ph.D. Molecular Oncogenesis and Targeted Therapy 39 H. Eric Xu, Ph.D. Laboratory of Structural Sciences 40 Tao Yang, Ph.D. Laboratory of Skeletal Biology 43 Yu-Wen Zhang, M.D., Ph.D. Signal Transduction and Molecular Medicine 44 iii iii

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