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2015 Scientific Report

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Van Andel Research

Van Andel Research Institute | Scientific Report 2015 46

LABORATORY REPORTS Center for EPIGENETICS Peter A. Jones, Ph.D., D.Sc. Director The Center’s researchers study epigenetics and epigenomics in health and disease, with the ultimate goal of developing novel therapies to treat cancer and neurodegenerative diseases. The Center collaborates extensively with other VARI research groups and with external partners to maximize its efforts to develop therapies that target epigenetic mechanisms. A strand of DNA (pink) is enclosed by DNA methyltransferase 1 (blue). The addition of methyl groups to DNA by this enzyme can silence and regulate genes without changing the genetic sequence. DNA methylation is being studied in relation to cancer. 47

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