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2018 Scientific Report

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Center for Cancer and

Center for Cancer and Cell Biology Bart O. Williams, Ph.D. Director The Center’s scientists study the basic mechanisms and molecular biology of cancer and other diseases, with the goal of developing better diagnostics and therapies. 4 | VAN ANDEL RESEARCH INSTITUTE SCIENTIFIC REPORT

A depiction of arrestin binding by a phosphorylated and active rhodopsin. The cell membrane lipids are shown as cream colored, rhodopsin is blue, and arrestin is red. The phosphorylated C-terminal tail of rhodopsin binds to the N-domain (left) of the arrestin molecule. In the main contact region between the two molecules (central), arrestin accommodates the ICL2 helix of rhodopsin. In this fully activated state, the tip of arrestin’s C-domain contacts the membrane (right). Image by Parker de Waal of the Xu lab.

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