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2018 Scientific Report

  • Text
  • Institute
  • Biology
  • Methylation
  • Molecular
  • Mechanisms
  • Epigenetic
  • Michigan
  • Vari
  • Scientific

Pathology and

Pathology and Biorepository Core SCOTT D. JEWELL, Ph.D. Dr. Jewell earned his Ph.D. degree from The Ohio State University. He joined VARI in 2010 as a Professor, Director of the Program for Technologies and Cores, and Director of the Pathology and Biorepository Core. STAFF Bree Berghuis, B.S., HTL(ASCP), QIHC Alex Blanski, B.S. Melissa Dehollander, M.B.A., B.S. Brianne Docter, M.S. Kristin Feenstra, B.S. Phil Harbach, M.S. Meghan Hodges, B.S. Galen Hostetter, M.D. Eric Hudson, B.S. Carrie Joynt, B.S., HT Rob Montroy, B.S. Lori Moon, E.M.B.A. Chelsea Peterson, B.S. Daniel Rohrer, B.S., M.B.A. Lisa Turner, B.S., HT, QIHC(ASCP) SERVICES The Pathology and Biorepository Core integrates anatomic pathology expertise with biorepository and biospecimen science in order to assist in VARI’s research. We build upon historical strengths in standard histology, microscopy, and biobanking, and we apply best practices in biospecimen science. The pathology discipline provides complementary emphasis on high-quality biospecimens and interpretable results with which to validate experimental models and extend them to clinical samples, thereby advancing our common translational mission. The VARI Biorepository has been accredited by the College of American Pathologists (CAP) since 2012. Dr. Jewell serves as a committee member for the CAP Biorepository Accreditation Program. Dr. Jewell, with his experience in clinical trials and biobanking, and Dr. Hostetter, who is board-certified in anatomic pathology, are currently studying the effects of preanalytical variables in tissue collection and transport on the integrity of downstream analytes. The Core provides assessment of tumor suppressors and immunomodulators in tumor tissues and the application of genomic and epigenomic assays for biospecimens. The VARI biorepository is nationally and internationally recognized, serving as the NCI Comprehensive Biospecimen Resource for the Genotype-Tissue Expression Program (GTEX). In 2015, it was designated as the Biorepository Core Resource for the NCI Clinical Proteomic and Tumor Analysis Consortium (CPTAC) and as the biorepository for the Tuberous Sclerosis Alliance. In addition, we are moving into our seventh year of providing biorepository services for the Multiple Myeloma Research Foundation’s CoMMpass Study. The biorepository is serving the VARI-SU2C consortium for epigenetics clinical trials biobanking, collaborating with Drs. Jones and Baylin. Pathology Core services • Histology and diagnostic tissue services, including morphology, immunohistochemistry, in situ hybridization, and multiplex fluorescent IHC assays • Pathology review and annotation of clinical samples from VARI’s prospective and retrospective tissue collections • Design and construction of tissue microarrays • Digital imaging and spectral microscopy coupled with image analysis tools • Cell fractionation and biospecimen processing • Laser capture microdissection Biorepository Core services • Biospecimen kit construction, shipping, and tracking • Clinical trials biobanking coordination • Quality management program Dana Valley, B.A., ASQ CMQ/OE, CSSGB Anthony Watkins, A.S. 54 | VAN ANDEL RESEARCH INSTITUTE SCIENTIFIC REPORT

Flow Cytometry Core RACHAEL SHERIDAN, Ph.D. Rachael Sheridan earned her Ph.D. in biochemistry from the University of Wisconsin–Madison and also holds a professional cytometry certification, SCYM(ASCP). Prior to joining Van Andel Research Institute in October 2016, she was an instrumentation specialist in the University of Wisconsin Comprehensive Cancer Center Flow Cytometry Laboratory. STAFF Lori Moon, E.M.B.A. SERVICES The Core provides comprehensive flow cytometry analysis and sorting services in support of VARI research. Additional services include assistance with protocol development and training in data analysis. Flow cytometry services are provided using a Beckman Coulter MoFlo Astrios and Beckman Coulter CytoFLEX S. Available hematology equipment includes a VetScan instrument, a VetScan HMII, and a Shandon Cytospin 3. Kellie Sisson, B.S. VAN ANDEL RESEARCH INSTITUTE SCIENTIFIC REPORT | 55

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